Giant Poisonous Frogs are very similar in appearance to the more normal sort, save for their bright coloration; though it varies by species, they may be marked in splotches or stripes of red, yellow, or blue, sometimes combined with black or white. They are the smallest sort of giant frog, being around a foot or so in length.

They lack both the tongue attack of the more common giant frogs as well as the vicious talons of the killer variety. Instead, their skin secretes a toxin that is deadly on contact unless a saving throw vs. Poison is made; this saving throw is made at a bonus of +4, but if the roll succeeds, the victim must then save vs. Paralysis at normal odds or be paralyzed for 2d4 turns.